Following the Yamato's heroic actions in cleansing Earth from radiation in 2200, a fresh danger looms on the horizon a year later. With Earth on the path to recovery post-Gamilus conflict, the crew reunites upon intercepting a mysterious transmission from a white comet hurtling towards their planet. Reclaiming their beloved space fortress, they embark on a daring mission to thwart this impending threat and safeguard their newfound peace.