Doremi Harukaze, a seemingly unlucky but charming 3rd grader at Misora Elementary School, stumbles upon a peculiar shop that leads her to a fateful encounter with Majo Rika, a genuine witch. Unveiling Rika's true identity sets off a chain reaction where witches face a bizarre curse that transmutes them into magical frogs. To reverse this enchantment, Rika enlists Doremi as her apprentice, guiding her into the realm of sorcery. As Doremi embraces her newfound magical journey, her closest friends Hazuki Fujiwara and Aiko Senoo uncover her secret, prompting them to join the mystical ranks as well to safeguard their friend from a similar fate. Together, the trio embarks on a series of enchanting escapades, tackling challenging trials in pursuit of mastering the art of witchcraft.