Continuing the journey from its predecessor, Zoku Natsume Yuujinchou follows Natsume Takashi, a boy with the extraordinary ability to perceive youkai since childhood, accompanied by his guardian youkai, Madara, also known as Nyanko-sensei. Tasked with returning names inscribed in his grandmother Reiko's Book of Friends to the youkai in his town, Natsume encounters a mix of benevolent spirits, covetous entities eyeing the book, and malevolent beings intent on his demise. Amidst these encounters, Natsume embarks on a quest of self-discovery, unraveling the intricacies of his identity and his complex bond with the youkai world.