Following the aftermath of World War III, Japan grapples with the enduring consequences of the conflict that officially ended five decades prior. The landscape is scarred by enigmatic zones called 'Blackspots,' where the remnants of civilization lie contaminated and forsaken. Within these hazardous areas, individuals endowed with extraordinary powers, dubbed 'Needless,' emerge with abilities spanning from shape-shifting to pyromancy. Among them is Adam Blade, a formidable Needless boasting unparalleled regeneration and immense strength. To bring tranquility back to a war-ravaged Japan, Adam and his comrades unite to combat the malevolent research faction known as Simeon.