Kakashi Hatake, Naruto Uzumaki, Sakura Haruno, and Sai investigate the mysterious disappearance of powerful ninjas with unique abilities from various nations. Their search leads them to Hiruko, a former Konohagakure ninja thirsty for power, who has absorbed the missing ninjas' powers to become unstoppable. With Hiruko plotting to acquire more abilities and conquer the world, suspicions arise about Konohagakure's involvement. As Tsunade faces pressure to resolve the crisis, Kakashi proposes a risky plan that could cost him his life. Despite Naruto's objections, he is determined to save his mentor, braving all odds even against allies turned enemies.