In 2199, a war breaks out between the human race and the aggressive Gamilon aliens, leading to Earth's devastation. Facing extinction due to advanced alien tech, humans find hope when Queen Starsha offers aid. The secret to survival lies in the distant planet Iscandar and its Cosmo-Cleaner D, the sole cure for Earth's radiation. The catch? It's 148,000 light years away, and time is running out. Now, the fate of humanity rests on the shoulders of the Space Battleship Yamato's crew, racing against the clock on a perilous mission.