In a world where magic clashes with Academy City, Touma Kamijou, armed with the power of negation, steps up to defend those in danger against espers and magicians. With a mix of familiar and fresh faces joining the fray, allies and foes unite in the ongoing struggle. Toaru Majutsu no Index II follows Touma's comedic and action-packed journey as the stakes escalate. As a looming conflict looms ahead, the collision of magic and science sets the stage for a grand battle yet to unfold.