In a world where the powerful exoskeleton Infinite Stratos (IS) is reserved for female pilots, a groundbreaking revelation occurs when 15-year-old Ichika Orimura displays exceptional skill in piloting the IS. This unexpected talent leads to Ichika's enrollment in the prestigious Infinite Stratos Academy, an elite institution training female IS pilots. Reunited with childhood friends Houki Shinonono and Lingyin Huang, Ichika also forms a bond with Cecilia Alcott, a skilled IS representative hailing from the United Kingdom. Under the guidance of the formidable Chifuyu Orimura, a renowned pilot and Ichika's strict older sister, the group must unite to protect themselves and their academy from looming threats, navigating the challenges of their action-packed school life together.