In a world where monsters are commonplace, Ren, Aoi, Akira, and Minami dedicate themselves to eliminating violent creatures from their neighborhood. Their routine is disrupted by the arrival of Mana Livingston, a transfer student from America. As Mana integrates into their group, a mysterious threat looms on the horizon, signaling an imminent danger that will test their bonds. A fresh saga unfolds in the realm of Monster Strike with the introduction of Mana.