After inadvertently getting involved in a kidnapping, college student Yuuya Nomoto witnesses his friends' tragic end at the hands of Hitomi Uzaki, the high school girl they tried to abduct. Compelled to transport her to an undisclosed place, he becomes a pawn in a deadly showdown between two Therianthropes—humans fused with animal genes through advanced technology. Utilizing her ratel-enhanced speed and fearlessness, Hitomi triumphs in a brutal death match to rescue Yuuya. Awakening later, Yuuya hopes it was all a bad dream, only to realize he's now entangled in a covert battle among four major Japanese corporations vying for economic dominance. Bound to Hitomi as her involuntary ally, his fate hinges on her participation in the underground combat spectacle called Killing Bites.