Hiroshi is tasked with managing his company's branch in Mexico to harvest nectar from a special cactus. The Nohara family relocates tearfully from Kasukabe to embark on this new adventure. Intrigued by rumors of stylish Mexican girls, Shinnosuke eagerly anticipates their journey. Upon reaching Mardequellyovaca city, they face a life filled with uncertainties and peculiar neighbors. Unaware of the impending danger from carnivorous killer cactuses, the Nohara family must unite with their neighbors to battle the deadly threat and protect their new home from the 'Killer Cactus'.