In Otoboku 2, the story unfolds two years post Mizuho's graduation, focusing on Chihaya Mikado, the new central character. Chihaya, plagued by school harassment and a deep distrust of men, finds refuge at Seio Girl's School at the insistence of his concerned mother. Assuming the identity of Chihaya Kisakinomiya and cross-dressing as a girl, he joins the school where his mother once studied. Here, Chihaya encounters Kaoruko Nanahara, a significant figure who previously rescued him from a troublesome encounter. As Chihaya settles into the dormitory, his striking appearance, academic excellence, and past experiences quickly thrust him into the limelight, drawing both admiration and scrutiny.