In the realm of Windbloom, Arika Yumemiya enrolls at Garderobe Academy to train as an Otome—a virgin girl capable of wielding powerful HiME technology. Seeking her mother, a Meister Otome of elite status, Arika befriends Nina Wáng, a notable Otome, and Mashiro Blan de Windbloom, the kingdom's princess. Embracing academy life, Arika hones her skills, forges connections, and faces the perilous path of Otomehood, rife with political intrigue and personal sacrifices.